Seeff LB, Curto TM, Szabo G, et al. The name "milk thistle" derives from a feature of the leaves, which are prominently banded with splashes of white. Several studies have suggested that milk thistle may be beneficial for people with type 2 diabetes. 2016;5147468. doi:10.1155/2016/5147468. Although research is still emerging, milk thistle may be beneficial for conditions relating to the liver and gallbladder. By clicking Accept All Cookies, you agree to the storing of cookies on your device to enhance site navigation, analyze site usage, and assist in our marketing efforts. 2005;100(11):2583-91. doi:10.1111/j.1572-0241.2005.00262.x. Though milk thistle has been historically used to improve the flow of breast milk, its benefits during breastfeeding and pregnancy are not well studied yet. Hepatology. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. You may report side effects to Health Canada at 1-866-234-2345. There are other supplements that work similarly to milk thistle. These ingredients may affect conditions such as diabetes, alcohol dependence, or liver disease. However, more direct research is warranted in this regard. Milk thistle is a plant named for the white veins on its large prickly leaves. Consult with your healthcare provider if you experience these and other side effects to find out the best way to proceed. We explore the potential health benefits of milk thistle below. Fried MW, Navarro VJ, Afdhal N, et al. Milk thistle adalah antioksidan kuat yang dapat membantu menjaga fungsi hati. It seems to help lower blood sugar. Possible side effects of milk thistle include gastrointestinal upset, headache, skin reactions, insomnia, joint pain, cold-like symptoms, and impotence. But are there any proven health benefits of it? Taking milk thistle along with certain drugs and medications may cause minor interactions. Enter your medication into the WebMD interaction checker, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Fitness vs. Take your next dose at the regular time. Milk thistle is an herbal remedy derived from the milk thistle plant, also known as Silybum marianum. Review of Clinical Trials Evaluating Safety and Efficacy of Milk Thistle (Silybum marianum [L.] Gaertn. Available for Android and iOS devices. Milk thistle ( Silybum marianum L. A 2016 study found that milk thistle improved diet-induced liver damage in mice. Nanjan MJ, Betz J. Resveratrol for the management of diabetes and its downstream pathologies. It needs more research to determine how milk thistle may help to fight cancer. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. You may report side effects to FDA at 1-800-FDA-1088. Weight Loss for Health and Longevity, Science Reveals How Red Meat Harms the Heart, Flavored Vapes Still in Stores Despite Federal Ban, New COVID Antiviral Pills: What You Need to Know, Dr. Whyte's Book: Take Control of Your Cancer Risk, WebMD Loses Cherished Leader Kristy Hammam, Health News and Information, Delivered to Your Inbox. Finally, those with hormone-sensitive conditions, including certain cancers, may need to avoid using milk thistle. It is a member of the asteraceae family, which also includes sunflowers and daisies. 2019;33(6):1627-1638. doi:10.1002/ptr.6361. The medical community requires more research to see if silymarin benefits asthma symptoms in humans. Milk thistle (Silybum marianum) is a herb loaded with antioxidants and is known for its anti-inflammatory properties. If you have any questions about storage, ask your pharmacist. Although milk thistle may be helpful in hepatitis C, more research is needed to support these claims. Milk Thistle: Effects on Liver Disease and Cirrhosis and Clinical Adverse Effects: Summary, AHRQ Evidence Report Summeries, National Center for Biotechnology Information, U.S. National Library of Medicine. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. If left untreated, anaphylaxis can lead to shock, coma, cardiac or respiratory failure, or even death. Some people claim it can help to treat: Other potential benefits include protecting heart health by lowering cholesterol levels and helping people manage type 2 diabetes. Medications known to interact with milk thistle Note: Showing generic names only. Milk thistle may help to stop the spread of certain types of cancer. Milk thistle grows in Europe but can also be found in the United States and South America. Milk thistle may not be safe for everyone. Toxicity is also possible if too much milk thistle is taken. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Cymbalta side effects (more detail) 2012;308(3):274-82. doi:10.1001/jama.2012.8265. Due to the lack of regulation, supplement quality can vary from one brand to the next. There is no standard dose of milk thistle, so it is best to read the dosage suggested on the packaging. Phytother Res. Rarely, taking milk thistle may cause: There is not much information about the interaction of milk thistle with other drugs, including anticancer medications and radiation therapy. (2021). Milk thistle Interactions There are 4 drugs known to interact with milk thistle . Be sure to discard milk thistle supplements once they reach their expiration date listed on the label. But the herb is also believed to be beneficial for other health issues. Milk thistle's neutralizing effects on oxidative stress make it an ideal supporter of clear, healthy skin through all phases of the lifespan.*. Dupuis ML, Conti F, Maselli A, et al. These reactions may occur if you have an allergy to milk thistle. It could also have similar effects on the body to estrogen. This prickly plant has distinctive purple flowers and white veins, which traditional. Milk thistle is generally thought to be safe, but you still may experience side effects when taking it. Deng JW, Shon JH, Shin HJ, et al. Milk thistle may produce allergic reactions, which tend to be more common among people who are allergic to plants in the same family (for example, ragweed, chrysanthemum, marigold, and daisy). Effects of vitamin E on chronic hepatitis C genotype 3: a randomized, double-blind, placebo-controlled study. 3. StatPearls Publishing; 2022. It is now found throughout the world. Use milk thistle as directed to prevent an overdose. If you miss a dose, take it as soon as you remember. You may report side effects to FDA at 1-800-FDA-1088. More studies with human participants could allow scientists to say with certainty that milk thistle supports a persons immune system. Ask your doctor or pharmacist about using this product safely. NCCIH has provided this material for your information. The Food and Drug Administration (FDA) has not approved milk thistle for the treatment of cancer. [1] Silymarin is a standardized preparation extracted from the fruits (seeds) of milk thistle. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. Scientists think this creates a detoxifying effect, which is why milk thistle may be beneficial for liver problems. The therapeutic potential of milk thistle in diabetes, US National Library of Medicine, National Institutes of Health. The terms milk thistle and silymarin are often used interchangeably. A 2015 study in worms found that milk thistle increased resistance to oxidative stress. The extract of the seeds of milk thistle contains a number of substances, collectively called silymarin. Therefore, it may be best to avoid milk thistle during these life stages. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Potensi Tinggi Setiap kapsul mengandung 1.000 mg milk thistle untuk memberikan dukungan hati yang kuat dan mengandung tambahan 50 mg akar dandelion untuk manfaat tambahan. 1997-. How should we deal with preliminary information such as this? Milk thistle can also cause an allergic reaction in some people. Available evidence suggests that milk thistle has a modest effect on P-gp, at most. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. Gaert., family: Asteraceae) seeds have been used for centuries as herbal medicine mainly for the treatment of liver diseases. Clinical practice shows that milk thistle has a good anti-liver injury effect and can be used to prevent anti-tuberculosis drug-induced liver injury. In: StatPearls. Bunchorntavakul C, Wootthananont T, Atsawarungruangkit A. You should follow dosage directions to prevent side effects. Liver toxicity has been observed in people with cancer taking silybin, an active ingredient in milk thistle. Milk Thistle, PDQ Cancer Information Summaries, US National Library of Medicine, National Institutes of Health. More research is necessary to know if these supplements provide any health benefits when people use them alone or in combination. List Milk Thistle Capsule side effects by likelihood and severity. Milk thistle may help to promote healthy skin. Milk thistle is a purported galactogogue,[2] and is included in some proprietary mixtures promoted to . It is not yet clear whether milk thistle is equally beneficial for bone loss with a different cause. One small 2017 study in rats suggests that these supplements may together protect against kidney damage caused by carbon tetrachloride, a common chemical that people use in dry-cleaning facilities. If it is near the time of the next dose, skip the missed dose. Check out the infographic below to learn more about the benefits of milk thistle.SaveIllustration: StyleCraze Design Team. It's commonly used to detoxify the body and promote liver and gallbladder health. Similar supplements to milk thistle include: Please talk with your healthcare provider about the best supplement for you. Voroneanu L, Nistor I, Dumea R, Apetrii M, Covic A. Silymarin in type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials. Milk thistle (silymarin) is a flowering herb related to the daisy and ragweed family. Over-indulging in this powerful herb may do you more harm than you know. Merlin Annie Raj is a Registered Dietitian based out of Hyderabad, India. Ebrahimpour, K.; Gargari, B.; Mobasseri, M. et al. However, the review's authors warned that the quality of the studies was poor and that more research is needed before milk thistle should be recommended for use. J Diabetes Res. Yang Z, Zhuang L, Lu Y, Xu Q, Chen X. Of the total drug interactions, 3 are moderate, and 1 is minor. Always speak with a healthcare provider before taking a supplement to ensure that the supplement and dosage are appropriate for your individual needs. Hepatology. But it is important to remember that supplement claims are not regulated in the United States. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. People with diabetes should use caution. Duplication is encouraged. Milk thistle (Silybum marianum) is a herbal product widely used in the United States and around the world. Medical research on milk thistle and liver health has led to mixed results. 1982;17:51721. Achufusi TGO, Patel RK. Fried, M.; Navarro, V.; Afdhal, N. et al. Liquid forms of this product may contain sugar and/or alcohol. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Before using this product, tell your doctor or pharmacist of all the products you use. However, there is a lack of . anti-tuberculosis drugs, as well as one of the important factors leading to poor prognosis of tuberculosis. Common Names:milk thistle, Mary thistle, holy thistle, Latin Names:Silybum marianum, synonym Carduus marianus. Evidence and risks, Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT, protecting the liver, immune system, and kidneys, providing antiviral, antifungal, and antibacterial properties, reducing the risk of diabetes, arthritis, and obesity. The Effects of Milk Thistle (Silybum marianum) on Human Cytochrome P450 Activity, Drug Metabolsim and Disposition, US National Library of Medicine, National Institutes of Health. Get emergency medical help if you have any of these signs of an allergic reaction while taking milk thistle: hives; difficult breathing; swelling of your face, lips, tongue, or throat. What Is Complementary, Alternative, or Integrative Health? Milk thistle is also available as a tea. How this happens is yet to be studied. All rights reserved. Learn, Medical News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and medical journals and associations. In clinical trials, milk thistle appears to be well tolerated in recommended doses. Effect of silymarin on biochemical indicators in patients with liver disease: systematic review with meta-analysis. In animal studies, the antioxidant and radical-scavenging properties of silibinin in milk thistle were found to reduce tumors (16). Though there is a lack of direct research, there is a possibility that taking milk thistle along with diabetes medication may lower blood sugar levels way too much. Yes, you can drink alcohol while taking milk thistle. Common side effects of milk thistle may include: indigestion, bloating, gas, stomach pain; diarrhea; or. It found that cholesterol levels were lower in people taking milk thistle to treat diabetes than those taking a placebo. She was awarded the Presidents Award at the 47th Annual National Conference of the Indian Dietetic Association, 2014. Some people also call it Mary thistle and holy thistle. Han YU, Guo D, Chen Y, et al. Milk thistle has not been implicated in causing liver injury and is still used widely as a liver tonic in patients with acute and chronic liver diseases. It is native to Mediterranean countries. Investigating the Potential for Toxicity From Long-Term Use of the Herbal Products, Goldenseal and Milk Thistle, Toxicologic Pathology, US National Library of Medicine, National Institutes of Health. We include products we think are useful for our readers. 2007;2007(4):CD003620. Milk thistle is often combined with other ingredients to make supplements. This article will explore the potential uses of milk thistle. It is also unknown whether milk thistle is safe for children. Keep in mind, though, that it is unknown if milk thistle tea provides the same suggested benefits as milk thistle supplements. nausea, loss of appetite. He specializes Professional Certificate In Food, Nutrition & Health. Milk thistle is now found throughout the eastern United States, California, South America, Africa, Australia, and Asia. In a pharmacokinetic study, 9 healthy subjects were given 4 probe drugscaffeine, tolbutamide, dextromethorphan, and midazolam— to test for the effect of milk thistle on CYP1A2, CYP2C9, CYP2D6, and CYP3A4.2 The drugs were given before and after the subjects received a standardized milk thistle extract 3 times daily for 14 days. 2014;10(1):31-35. doi:10.17925/EE.2014.10.01.31. The therapeutic potential of milk thistle in diabetes. Talk to your pharmacist for more details. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. Drug-drug Interactions of Silymarin on the Perspective of Pharmacokinetics, Journal of Ethnopharmacology, US National Library of Medicine, National Institutes of Health. Phytomedicine. Oxidative stress is a potential cause of Alzheimers disease. For centuries, this herb has been used in fighting hangovers (9). Loose stools or upset stomach may occur. Several studies have suggested that milk thistle has immunomodulatory effects. Milk thistle is native to the Mediterranean region. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. Therefore, it is not known whether milk thistle or silymarin should be used to treat cirrhosis. He graduated from SRM University, Chennai, and has a Professional Certificate in Food, Nutrition & Research from Wageningen University.